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However, serious complications, such as gallstones and intestinal obstruction, have been reported in a small proportion of GLP-1 users

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Meal Timing and Composition A 2021 multidisciplinary expert consensus published in Postgraduate Medicine (Taylor et al.) recommends for GLP-1 agonist GI management: Smaller, more frequent meals 3-4 smaller meals spaced 3-4 hours apart reduces the gastric load at any given time Reduce dietary fat high-fat meals slow gastric emptying further, compounding the delay caused by GLP-1 activation Avoid spicy foods capsaicin and other irritants exacerbate GI inflammation in the context of slowed motility Prioritize soft, easy-to-digest foods soups, yogurt, and well-cooked vegetables reduce mechanical stress on the stomach Hydration Adequate fluid intake supports gastric motility and reduces constipation one of the secondary causes of abdominal pain on retatrutide