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Unlike, GLP-1 and Gcg, GIP is not derived from preproglucagon and does not cause a reduction in body weight (Baggio and Drucker, An alternative approach aiming to maximize the efficacy of GLP-1 involves the delivery of nuclear receptor agonists to specific tissues characterized by the expression of GLP-1R
21 Remarkably, even in HF-free patients with morbid obesity, cardiac abnormalities can be seen that are consistent with left ventricular (LV) remodelling and dysfunction, including greater LV mass, LV diastolic dysfunction and elevated LV filling pressure
PMCID: PMC4144092
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