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Epub 2022 Mar 9

Both MASH and liver fibrosis are significant risk factors for the onset of cirrhosis and hepatocellular carcinoma, leading causes of liver transplantation [4, 5] and responsible for over 800,000 deaths worldwide [6]

This is why the decision to combine these medications requires careful, individualized clinical judgment rather than a blanket recommendation in either direction

Clinical evidence in MS patients A 2025 conference abstract presented at the American Academy of Neurology analysed data from 7,046 MS patients taking GLP-1 agonists (including semaglutide) compared to matched controls over five years