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Your doctor should assess several factors before approving discontinuation, including your current weight status and trajectory, the presence and control of obesity-related comorbidities (type 2 diabetes, hypertension, sleep apnea, cardiovascular disease), your readiness and capacity to implement intensive lifestyle modifications, available support systems and resources, and your history of weight cycling or previous weight loss attempts

The finding, made jointly by researchers at Stanford Medicine and at Harvard Medical School and published in Nature Metabolism , further cements the critical role the molecule, called lac-phe, plays in metabolism, exercise and appetite

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This means that body fat percentage affects distribution volume less than total body weight