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grant/research support received from Boehringer Ingelheim, Novartis Pharma, MSD Sharp & Dohme GmbH, Metacure, AstraZeneca, GlaxoSmithKline, Roche Pharma AG, Novo Nordisk Pharma GmbH and ToleRx, and has served on the speaker's bureau for AstraZeneca, Berlin Chemie AG, Boehringer Ingelheim, Lilly Deutschland GmbH, MSD Sharp & Dohme GmbH, Novartis Pharma, Novo Nordisk A/S, Roche Pharma