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This central action leads to reduced appetite and increased satiety, contributing to weight loss

However, exposure to temperatures exceeding 30C or direct heat sources (such as radiators, direct sunlight, or hot vehicles) can potentially reduce the medication's effectiveness

Two to three sessions per week of compound exercises (squats, lunges, rows, presses, deadlifts) provides enough stimulus to preserve existing muscle and potentially regain some of what was lost

Some providers prescribe ondansetron proactively alongside the first few dose increases, particularly for patients with histories of motion sickness or pregnancy nausea, as these populations tend to experience stronger GLP-1 side effects