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Immune checkpoint molecules like PD-1 (programmed death-1) and CTLA-4 (Cytotoxic T lymphocyte-associated antigen-4) function as negative regulators of immune activation, and when triggered by tumor or tumor-associated cells, they suppress immune responses (105, 125128)

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A new method for evaluating nuisance of odorants by chemical and sensory analyses and the assessing of masked odors by olfactometry