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pylori releases the protein CagA (cytotoxin-associated gene A) which potently inhibits pathogenic amyloid assemblies, via blocking multiple steps (primary nucleation, secondary nucleation, and elongation) for formation in Alzheimers disease, Parkinsons disease and type 2 diabetes

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This in turn enables the activation of defense signaling proteins and transcription factors which helps to establish innate immune memory (Lindermayr and Yildirim, 2025)