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Finally, KDs anti-inflammatory actions extend to the modulation of the Akt/GSK-3/CREB signaling pathway, mediated by histone acetylation in the promoter region of the metabotropic glutamate receptor 5 (mGluR5) in a rat model of PD [44]

Clinical efficacy was demonstrated in the Phase 3 OASIS program, which evaluated daily doses up to 50 mg

4), mucosal damage still persisted, suggesting that mucosal GSH down regulation may be of relevance only in the acute phase of colitis and that its chronic development is independent of GSH status

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