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[67] demonstrated that, in normal human gingival fibroblasts, curcumin can also act as a pro-oxidant: incubation with 1050 M curcumin provoked significant ROS generation, which was accompanied by loss of mitochondrial membrane potential, an early indicator of mitochondrial dysfunction, and externalization of phosphatidylserine, a hallmark of apoptosis

The findings suggest that GHK-Cu acts through multiple biological pathways to counteract Alzheimer's-related degeneration

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