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[DOI] [PubMed] [Google Scholar] 40.Pirmohamed M, Madden S, Park BK

The presence of adjuvants in vaccines is primarily associated with local injection-site reactions and systemic responses such as fever and fatigue

So a compound that looks clean in rat intestinal epithelium can still provoke a response in human tissue

However, their limited ability to cross the BBB (under 6%) hinders routine formulations from achieving therapeutic concentrations in the brain, significantly restricting their clinical applicability 13